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Nrf2-regulated antioxidant response ameliorating ionizing radiation-induced damages explored throughin vitroand molecular dynamics simulations

28 Oct 2022

Abstract excerpt

This study aims to investigate the mechanism of natural antioxidant ferulic acid (FA) in reducing oxidative stress followed by its inhibitory effect on the Keap1-Nrf2 complex. FA was treated ex vivo with human blood for 30 min at 37 °C ± 1 °C and exposed to 1.5 Gy of γ- rays of 60Co (0.789 Gy/min) and allowed for repair for an hour at 37 °C ± 1 °C. FA's free radical scavenging capacity was measured using...

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PMID: 36307909
DOI: 10.1080/07391102.2022.2137245

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