Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bioinformatic and computational analysis for predominant mutations of the Nrf2/Keap1 complex in pediatric leukemia.

Journal of biomolecular structure & dynamics - 1 Aug 2021

Akın-Balı Dilara Fatma, Al-Khafaji Khattab, Aktas Sedef Hande, Taskin-Tok Tugba

Abstract excerpt

The levels of reactive oxygen species (ROS) are tightly controlled and regulated by Nuclear Factor Erythroid-2-Like 2 (Nrf2) transcription factor, which is the main regulator of antioxidant responses and its suppressor protein Kelch-like ECH-associated protein 1 (Keap1). Our previous study has identified six novel changes in Nrf2/Keap1 pathway in pediatric ALL, which were described for the first time. These...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kelch-Like ECH-Associated Protein 1

Share to Leukemia

Share to Mutation

Share to NF-E2-Related Factor 2

Source

Identifiers

PMID: 32469262
DOI: 10.1080/07391102.2020.1775702

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bioinformatic and computational analysis for predominant mutations of the Nrf2/Keap1 complex in pediatric leukemia.PMID 32469262Read ↗

Identification of novel Nrf2/Keap1 pathway mutations in pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

New insights into the mechanism of Keap1-Nrf2 interaction based on cancer-associated mutations.Semantic proximity Read ↗

Effects of the I682F mutation on JAK2's activity, structure and stability.Semantic proximity Read ↗

Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1.Semantic proximity Read ↗

Effect of novel leukemia mutations (K75E & E222K) on interferon regulatory factor 1 and its interaction with DNA: insights from molecular dynamics simulations and docking studies.Semantic proximity Read ↗

In Silico Analysis of the Association of Damage Suppressor (Dsup) Proteins of Tardigrades with BRCA1 Protein of Homo sapiensSemantic proximity Read ↗

Investigating the structural impacts of I64T and P311S mutations in APE1-DNA complex: a molecular dynamics approach.Semantic proximity Read ↗

Complex formation dynamics of native and mutated pyrin's B30.2 domain with caspase-1.Semantic proximity Read ↗

The effects of R683S (G) genetic mutations on the JAK2 activity, structure and stability.Semantic proximity Read ↗

Interdisciplinary Study of the Effects of Dipeptidyl-Peptidase III Cancer Mutations on the KEAP1-NRF2 Signaling Pathway.Semantic proximity Read ↗

Structural and Dynamic Characterization of Mutated Keap1 for Varied Affinity toward Nrf2: A Molecular Dynamics Simulation Study.Semantic proximity Read ↗

Effects of mutants in bHLH region on structure stability and protein-DNA binding energy in DECs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.