Article

In Silico Discovery of Fructosamine-3-Kinase Inhibitors Targeting the Nrf2-Mediated Antioxidant Response in Cancer Cells: A Molecular Dynamics Approach

2026-03-25

Abstract excerpt

<title>Abstract</title> <p>Fructosamine-3-kinase is an enzyme responsible for deglycating the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) which regulates the expression of numerous genes involved in the cellular defence against oxidative stress. To identify inhibitors against FN3K, which may disrupt antioxidant-homeostasis in cancer cells, noncovalent docking was performed for a set of...

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Literature Corpus work: cd5235f5-0eb2-5a49-abc4-b0e984989829
DOI: 10.21203/rs.3.rs-9171204/v1

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