Article
Interferon-beta induces major histocompatibility complex of class I (MHC-I) expression and a proinflammatory phenotype in cultivated human astrocytes.
Differentiation; research in biological diversity - 1 Jan 2000
Ignarro Raffaela Silvestre, Bombeiro André Luis, Chiarotto Gabriela Bortolança, Cartarozzi Luciana Politti, Coser Lilian de Oliveira, Ghizoni Enrico, Tedeschi Helder, Cendes Fernando, Lopes-Cendes Iscia, Rogerio Fabio, Oliveira Alexandre Leite Rodrigues de
Abstract excerpt
Major histocompatibility complex class I (MHC-I) has been implicated in several types of neuroplasticity phenomena. Interferon beta-1b (IFN-β) increases MHC-I expression by motoneurons after sciatic nerve crush in mice, improving axonal growth and functional recovery. Additionally, IFN-β induces glial hypertrophy associated with upregulation of glial fibrillary acidic protein (GFAP) and MHC-I in murine astrocytes...
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