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Article

Mesenchymal stem cells instruct a beneficial phenotype in reactive astrocytes.

Glia - 1 May 2021

Vigo Tiziana, Voulgari-Kokota Androniki, Errede Mariella, Girolamo Francesco, Ortolan Jasmin, Mariani Maria C, Ferrara Giovanni, Virgintino Daniela, Buffo Annalisa, Kerlero de Rosbo Nicole, Uccelli Antonio

Abstract excerpt

Transplanted mesenchymal stromal/stem cells (MSC) ameliorate the clinical course of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS), reducing inflammation and demyelination. These effects are mediated by instructive cross-talk between MSC and immune and neural cells. Astroglial reaction to injury is a prominent feature of both EAE and MS. Astrocytes constitute a relevant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33381863
DOI: 10.1002/glia.23958

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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