Article
A genome-wide gene-based gene-environment interaction study of breast cancer in more than 90,000 women.
Cancer research communications - 1 Apr 2022
Wang Xiaoliang, Chen Hongjie, Middha Kapoor Pooja, Su Yu-Ru, Bolla Manjeet K, Dennis Joe, Dunning Alison M, Lush Michael, Wang Qin, Michailidou Kyriaki, Pharoah Paul D P, Hopper John L, Southey Melissa C, Koutros Stella, Beane Freeman Laura E, Stone Jennifer, Rennert Gad, Shibli Rana, Murphy Rachel A, Aronson Kristan, Guénel Pascal, Truong Thérèse, Teras Lauren R, Hodge James M, Canzian Federico, Kaaks Rudolf, Brenner Hermann, Arndt Volker, Hoppe Reiner, Lo Wing-Yee, Behrens Sabine, Mannermaa Arto, Kosma Veli-Matti, Jung Audrey, Becher Heiko, Giles Graham G, Haiman Christopher A, Maskarinec Gertraud, Scott Christopher, Winham Stacey, Simard Jacques, Goldberg Mark S, Zheng Wei, Long Jirong, Troester Melissa A, Love Michael I, Peng Cheng, Tamimi Rulla, Eliassen Heather, García-Closas Montserrat, Figueroa Jonine, Ahearn Thomas, Yang Rose, Evans D Gareth, Howell Anthony, Hall Per, Czene Kamila, Wolk Alicja, Sandler Dale P, Taylor Jack A, Swerdlow Anthony J, Orr Nick, Lacey James V, Wang Sophia, Olsson Håkan, Easton Douglas F, Milne Roger L, Hsu Li, Kraft Peter, Chang-Claude Jenny, Lindström Sara
Abstract excerpt
Background: Genome-wide association studies (GWAS) have identified more than 200 susceptibility loci for breast cancer, but these variants explain less than a fifth of the disease risk. Although gene-environment interactions have been proposed to account for some of the remaining heritability, few studies have empirically assessed this. Methods: We obtained genotype and risk factor data from 46,060 cases and...
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