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Article

Improved estimation of SNP heritability using Bayesian multiple-phenotype models.

European journal of human genetics : EJHG - 1 May 2018

Elhezzani Najla Saad

Abstract excerpt

Linear mixed models (LMM) are widely used to estimate narrow sense heritability explained by tagged single-nucleotide polymorphisms (SNPs). However, those estimates are valid only if large sample sizes are used. We propose a Bayesian covariance component model (BCCM) that takes into account the genetic correlation among phenotypes and genetic correlation among individuals. The use of the BCCM allows us to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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PMID: 29440776
DOI: 10.1038/s41431-018-0100-z
PMCID: PMC5945852

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CHURC1

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