Article
Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium.
International journal of cancer - 1 Nov 2017
Barrdahl Myrto, Rudolph Anja, Hopper John L, Southey Melissa C, Broeks Annegien, Fasching Peter A, Beckmann Matthias W, Gago-Dominguez Manuela, Castelao J Esteban, Guénel Pascal, Truong Thérèse, Bojesen Stig E, Gapstur Susan M, Gaudet Mia M, Brenner Hermann, Arndt Volker, Brauch Hiltrud, Hamann Ute, Mannermaa Arto, Lambrechts Diether, Jongen Lynn, Flesch-Janys Dieter, Thoene Kathrin, Couch Fergus J, Giles Graham G, Simard Jacques, Goldberg Mark S, Figueroa Jonine, Michailidou Kyriaki, Bolla Manjeet K, Dennis Joe, Wang Qin, Eilber Ursula, Behrens Sabine, Czene Kamila, Hall Per, Cox Angela, Cross Simon, Swerdlow Anthony, Schoemaker Minouk J, Dunning Alison M, Kaaks Rudolf, Pharoah Paul D P, Schmidt Marjanka, Garcia-Closas Montserrat, Easton Douglas F, Milne Roger L, Chang-Claude Jenny
Abstract excerpt
Investigating the most likely causal variants identified by fine-mapping analyses may improve the power to detect gene-environment interactions. We assessed the interplay between 70 single nucleotide polymorphisms identified by genetic fine-scale mapping of susceptibility loci and 11 epidemiological breast cancer risk factors in relation to breast cancer. Analyses were conducted on up to 58,573 subjects (26,968...
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