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STAT3 and the STAT3‑regulated inhibitor of apoptosis protein survivin as potential therapeutic targets in colorectal cancer (Review)

24 Sept 2024

Abstract excerpt

Colorectal cancer (CRC) is one of the leading types of cancer worldwide.CRC development has been associated with the constitutive activation of signal transducer and activator of transcription 3 (STAT3).STAT3 is a master regulator of inflammation during cancer-associated colitis, and becomes upregulated in CRC.In CRC, STAT3 is activated by IL-6, among other pro-inflammatory cytokines, inducing the expression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39355529
DOI: 10.3892/br.2024.1863

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