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Adeno-Associated Viruses for Modeling Neurological Diseases in Animals: Achievements and Prospects

15 May 2022

Abstract excerpt

Adeno-associated virus (AAV) vectors have become an attractive tool for efficient gene transfer into animal tissues. Extensively studied as the vehicles for therapeutic constructs in gene therapy, AAVs are also applied for creating animal models of human genetic disorders. Neurological disorders are challenging to model in laboratory animals by transgenesis or genome editing, at least partially due to the...

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PMID: 35625877
DOI: 10.3390/biomedicines10051140

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