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Re‐adapting T cells for cancer therapy: from mouse models to clinical trials

13 Dec 2013

Abstract excerpt

Adoptive T-cell therapy involves the isolation, expansion, and reinfusion of T lymphocytes with a defined specificity and function as a means to eradicate cancer. Our research has focused on specifying the requirements for tumor eradication with antigen-specific T cells and T cells transduced to express a defined T-cell receptor (TCR) in mouse models and then translating these strategies to clinical trials. Our...

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PMID: 24329795
DOI: 10.1111/imr.12141

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