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Article

Comparative proteomics of the two T. brucei PABPs suggests that PABP2 controls bulk mRNA

24 Jul 2018

Abstract excerpt

Poly(A)-binding proteins (PABPs) regulate mRNA fate by controlling stability and translation through interactions with both the poly(A) tail and eIF4F complex. Many organisms have several paralogs of PABPs and eIF4F complex components and it is likely that different eIF4F/PABP complex combinations regulate distinct sets of mRNAs. Trypanosomes have five eIF4G paralogs, six of eIF4E and two PABPs, PABP1 and PABP2....

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PMID: 30040867
DOI: 10.1371/journal.pntd.0006679

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