Article
The role of mutations and overexpression of the fibroblast growth factor receptor-3 in bladder cancer.
Minerva medica - 1 Dec 2015
Wang Q Y, Zhao Y, Zhang R
Abstract excerpt
Bladder cancer (BC) is the seventh most common cancer worldwide. Throughout the last decade, several studies demonstrated that the fibroblast growth factor (FGF) signalling is altered in a significant proportion of patients with BC. FGF receptor (FGFR) 3 may thus serve as a promising biomarker for BC. Mutations of this gene are prevalent in BC (e.g., found in 74% of non-invasive papillary tumours), suggesting...
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