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Article

Octamer motif mediates transcriptional repression of HSV immediate-early genes and octamer-containing cellular promoters in neuronal cells.

Neuron - 1 Feb 1990

Kemp L M, Dent C L, Latchman D S

Abstract excerpt

C1300 mouse neuroblastoma cells are nonpermissive for infection with herpes simplex virus owing to a failure of viral immediate-early gene transcription following infection. The weak activity of the immediate-early gene promoters in these cells is mediated by the binding of a repressor factor to...

Topics

Animals
Base Sequence
Chloramphenicol O-Acetyltransferase
Gene Expression Regulation, Viral
Genes, Viral
Herpes Simplex
Molecular Sequence Data
Mutation
Neurons
Promoter Regions, Genetic
Simplexvirus
Transcription, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transfection

Tumor Cells, Cultured

Source

Identifiers

PMID: 2155008
DOI: 10.1016/0896-6273(90)90096-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2155008-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Octamer motif mediates transcriptional repression of HSV immediate-early genes and octamer-containing cellular promoters in neuronal cells.PMID 2155008Read ↗

An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity.Semantic proximity Read ↗

Regulation and cell-type-specific activity of a promoter located upstream of the latency-associated transcript of herpes simplex virus type 1Semantic proximity Read ↗

Direct interactions of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta protein with the cellular protein octamer-1 and DNA are critical for specifying transactivation of a delayed-early promoter and stimulating viral reactivation.Semantic proximity Read ↗

Repressor element-1 silencing transcription factor/neuronal restrictive silencer factor (REST/NRSF) can regulate HSV-1 immediate-early transcription via histone modificationSemantic proximity Read ↗

Regulation of Human Cytomegalovirus Immediate-Early Gene ExpressionSemantic proximity Read ↗

EBNA-2 transactivates a lymphoid-specific enhancer in the BamHI C promoter of Epstein-Barr virusSemantic proximity Read ↗

Repression of gene expression upon infection of cells with herpes simplex virus type 1 mutants impaired for immediate-early protein synthesisSemantic proximity Read ↗

Analysis of the promoter and cis-acting elements regulating expression of herpes simplex virus type 2 latency-associated transcripts.Semantic proximity Read ↗

Defective octamer-dependent transcription is responsible for silenced immunoglobulin transcription in Reed-Sternberg cells.Semantic proximity Read ↗

A cis-acting element in the major immediate-early (IE) promoter of human cytomegalovirus is required for negative regulation by IE2Semantic proximity Read ↗

The transcription factor YY1 binds to negative regulatory elements in the human cytomegalovirus major immediate early enhancer/promoter and mediates repression in nonpermissive cellsSemantic proximity Read ↗

Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteinsSemantic proximity Read ↗

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