Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic evolution towards azole resistance in Candida glabrata clinical isolates unveils the importance of CgHxt4/6/7 in azole accumulation

21 Oct 2022

Abstract excerpt

The increasing prevalence of candidosis caused by Candida glabrata is related to its ability to acquire azole resistance. Although azole resistance mechanisms are well known, the mechanisms for azole import into fungal cells have remained obscure. In this work, we have characterized two hexose transporters in C. glabrata and further investigate their role as potential azole importers. Three azole susceptible C....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal resistance and susceptibility
Share to Fungal Infections and Studies
Share to Pneumocystis jirovecii pneumonia detection and treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36271293
DOI: 10.1038/s42003-022-04087-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic evolution towards azole resistance in Candida glabrata clinical isolates unveils the importance of CgHxt4/6/7 in azole accumulationPMID 36271293Read ↗

Comparative genomic and transcriptomic analyses unveil novel features of azole resistance and adaptation to the human host in Candida glabrata.Semantic proximity Read ↗

Disclosing azole resistance mechanisms in resistant Candida glabrata strains encoding wild-type or gain-of-function CgPDR1 alleles through comparative genomics and transcriptomics.Semantic proximity Read ↗

Membrane Proteome-Wide Response to the Antifungal Drug Clotrimazole in Candida glabrata: Role of the Transcription Factor CgPdr1 and the Drug:H+ Antiporters CgTpo1_1 and CgTpo1_2.Semantic proximity Read ↗

Most azole resistance mutations in the Candida albicans drug target confer cross-resistance without intrinsic fitness cost.Semantic proximity Read ↗

Multiple genome analysis of Candida glabrata clinical isolates renders new insights into genetic diversity and drug resistance determinantsSemantic proximity Read ↗

Azole-Resistant Alleles of ERG11 in Candida glabrata Trigger Activation of the Pdr1 and Upc2A Transcription Factors.Semantic proximity Read ↗

Azole resistance in Candida glabrata clinical isolates from global surveillance is associated with efflux overexpressionSemantic proximity Read ↗

Multiple mechanisms impact fluconazole resistance of mutant Erg11 proteins in Candida glabrataSemantic proximity Read ↗

An expanded toolkit of drug resistance cassettes for Candida glabrata , Candida auris , and Candida albicans leads to new insights into the ergosterol pathwaySemantic proximity Read ↗

Azole Resistance and ERG11 Mutation in Clinical Isolates of Candida tropicalisSemantic proximity Read ↗

Histone Acetylation Regulator Gcn5 Mediates Drug Resistance and Virulence of Candida glabrataSemantic proximity Read ↗

Set1-mediated histone H3K4 methylation is required for azole induction of the ergosterol biosynthesis genes and antifungal drug resistance in <i>Candida glabrata</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.