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Azole resistance in Candida glabrata clinical isolates from global surveillance is associated with efflux overexpression

13 May 2022

Abstract excerpt

OBJECTIVES: We evaluated the azole resistance mechanisms and epidemiology of fluconazole-resistant Candida glabrata from a global survey. METHODS: A total of 2992 Candida spp. isolates collected during 2018-2019 were susceptibility tested by the broth microdilution reference method following CLSI guidelines. Fluconazole-resistant C. glabrata isolates were submitted to whole genome sequencing and gene expression...

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PMID: 35577042
DOI: 10.1016/j.jgar.2022.05.004

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