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Bone Marrow Clonogenic Myeloid Progenitors from NPM1-Mutated AML Patients Do Not Harbor the NPM1 Mutation: Implication for the Cell-Of-Origin of NPM1+ AML.

Genes - 9 Jan 2020

Guardia Rafael Diaz de la, González-Silva Laura, López-Millán Belén, Rodríguez-Sevilla Juan José, Baroni Matteo L, Bueno Clara, Anguita Eduardo, Vives Susana, Palomo Laura, Lapillonne Helene, Varela Ignacio, Menendez Pablo

Abstract excerpt

The cell-of-origin of NPM1- and FLT3-mutated acute myeloid leukemia (AML) is still a matter of debate. Here, we combined in vitro clonogenic assays with targeted sequencing to gain further insights into the cell-of-origin of NPM1 and FLT3-ITD-mutated AML in diagnostic bone marrow (BM) from nine NPM1+/FLT3-ITD (+/-) AMLs. We reasoned that individually plucked colony forming units (CFUs) are clonal and reflect the...

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PMID: 31936647
DOI: 10.3390/genes11010073
PMCID: PMC7017102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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