Article
Determination of complex subclonal structures of hematological malignancies by multiplexed genotyping of blood progenitor colonies.
Experimental hematology - 1 Jan 2018
Nice Francesca L, Massie Charlie E, Klampfl Thorsten, Green Anthony R
Abstract excerpt
Current next-generation sequencing (NGS) technologies allow unprecedented insights into the mutational profiles of tumors. Recent studies in myeloproliferative neoplasms have further demonstrated that, not only the mutational profile, but also the order in which these mutations are acquired is relevant for our understanding of the disease. Our ability to assign mutation order from NGS data alone is, however,...
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