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Article

Mutational profiling in suspected triple-negative essential thrombocythaemia using targeted next-generation sequencing in a real-world cohort.

Journal of clinical pathology - 1 Dec 2021

Michail Olga, McCallion Patrick, McGimpsey Julie, Hindley Andrew, Greenfield Graeme, McAllister Roisin, Feerick John, Arnold Claire, Cross Nick, Cuthbert Robert, McMullin Mary F, Catherwood Mark A

Abstract excerpt

Essential thrombocythaemia (ET) is driven by somatic mutations involving the JAK2, CALR and MPL genes. Approximately 10% of patients lack driver mutations and are referred as 'triple-negative' ET (TN-ET). The diagnosis of TN-ET, however, relies on bone marrow examination that is not always performed in routine practice, and thus in the real-world setting, there are a group of cases with suspected...

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Calreticulin
High-Throughput Nucleotide Sequencing
Janus Kinase 2
Predictive Value of Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Thrombopoietin

Thrombocythemia, Essential

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PMID: 33144355
DOI: 10.1136/jclinpath-2020-206570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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