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Article

Structure-guided machine learning prediction of drug resistance mutations in Abelson 1 kinase

1 Jan 2021

Abstract excerpt

Kinases play crucial roles in cellular signalling and biological processes with their dysregulation associated with diseases, including cancers. Kinase inhibitors, most notably those targeting ABeLson 1 (ABL1) kinase in chronic myeloid leukemia, have had a significant impact on cancer survival, yet emergence of resistance mutations can reduce their effectiveness, leading to therapeutic failure. Limited effort,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34667533
DOI: 10.1016/j.csbj.2021.09.016

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