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Article

Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning.

eLife - 17 Feb 2025

Estevam Gabriella O, Linossi Edmond, Rao Jingyou, Macdonald Christian B, Ravikumar Ashraya, Chrispens Karson M, Capra John A, Coyote-Maestas Willow, Pimentel Harold, Collisson Eric A, Jura Natalia, Fraser James S

Abstract excerpt

Mutations in the kinase and juxtamembrane domains of the MET Receptor Tyrosine Kinase are responsible for oncogenesis in various cancers and can drive resistance to MET-directed treatments. Determining the most effective inhibitor for each mutational profile is a major challenge for MET-driven cancer treatment in precision medicine. Here, we used a deep mutational scan (DMS) of ~5764 MET kinase domain variants to...

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Topics

Proto-Oncogene Proteins c-met
Humans
Protein Kinase Inhibitors
Drug Resistance, Neoplasm
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Protein Domains

Source

Open in PubMed Open full text

Identifiers

PMID: 39960754
DOI: 10.7554/eLife.101882
PMCID: PMC11832172

Genes

MET

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