Article
Dimerization of hepatitis E virus capsid protein E2s domain is essential for virus-host interaction.
PLoS pathogens - 1 Aug 2009
Li Shaowei, Tang Xuhua, Seetharaman J, Yang Chunyan, Gu Ying, Zhang Jun, Du Hailian, Shih J Wai Kuo, Hew Choy-Leong, Sivaraman J, Xia Ningshao
Abstract excerpt
Hepatitis E virus (HEV), a non-enveloped, positive-stranded RNA virus, is transmitted in a faecal-oral manner, and causes acute liver diseases in humans. The HEV capsid is made up of capsomeres consisting of homodimers of a single structural capsid protein forming the virus shell. These dimers are believed to protrude from the viral surface and to interact with host cells to initiate infection. To date, no...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.