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Roles of DNA damage repair and precise targeted therapy in renal cancer (Review)

19 Oct 2022

Abstract excerpt

The primary subtypes of renal cell carcinoma (RCC) include clear cell, papillary and chromophobe RCC. RCC occurs often due to loss of von Hippel‑Lindau (VHL) and accumulation of lipids and glycogen, and RCC cells may exhibit sensitivity to the disruption of normal metabolism or homologous recombination gene defect. Although the application of molecular‑targeted drugs (tyrosine kinase inhibitors) and immune...

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PMID: 36263616
DOI: 10.3892/or.2022.8428

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