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Article

Rapid assessment of 3-dimensional intra-tumor heterogeneity through cycling temperature capillary electrophoresis.

BMC research notes - 11 Aug 2023

Połeć Anna, Ekstrøm Per Olaf, Fougner Christian, Sørlie Therese, Norum Jens Henrik

Abstract excerpt

OBJECTIVE: Tumors are heterogeneous three-dimensional masses populated by numerous cell types, including distinct sub-clones of cancerous cells. Various sub-clones within the same tumor mass may respond differently to cancer treatment, and intra-tumor heterogeneity contributes to acquired therapeutic resistance. Thus, one tissue biopsy will in most cases not be representative of the entire genetic landscape of a...

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Identifiers

PMID: 37568187
DOI: 10.1186/s13104-023-06437-5
PMCID: PMC10416412

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