Article
The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm.
Proceedings of the National Academy of Sciences of the United States of America - 2 Mar 2021
Koopman Charlotte D, De Angelis Jessica, Iyer Swati P, Verkerk Arie O, Da Silva Jason, Berecki Geza, Jeanes Angela, Baillie Gregory J, Paterson Scott, Uribe Veronica, Ehrlich Ophelia V, Robinson Samuel D, Garric Laurence, Petrou Steven, Simons Cas, Vetter Irina, Hogan Benjamin M, de Boer Teun P, Bakkers Jeroen, Smith Kelly A
Abstract excerpt
The establishment of cardiac function in the developing embryo is essential to ensure blood flow and, therefore, growth and survival of the animal. The molecular mechanisms controlling normal cardiac rhythm remain to be fully elucidated. From a forward genetic screen, we identified a unique mutant, grime, that displayed a specific cardiac arrhythmia phenotype. We show that loss-of-function mutations in tmem161b...
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