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Article

Impact of ABCB1 Polymorphism on Levetiracetam Serum Concentrations in Epileptic Uygur Children in China.

Therapeutic drug monitoring - 1 Dec 2020

Zhao Ting, Yu Jing, Wang Ting-Ting, Feng Jie, Zhao Wen-Bo, Sun Li, Yu Lu-Hai, Li Hong-Jian, Sun Yan

Abstract excerpt

BACKGROUND: Interindividual variations in the efficacy of antiseizure medications make epilepsy treatment challenging. This is due to genetic factors such as gene polymorphisms in Adenosine-triphosphate (ATP)-binding cassette sub-family B member 1 (ABCB1). In this article, the impact of polymorphisms in the P-glycoprotein-encoding gene, ABCB1 (C1236T, G2677T/A, and C3435T), on levetiracetam disposition was...

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Identifiers

PMID: 32890316
DOI: 10.1097/FTD.0000000000000805
PMCID: PMC7664979

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