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Deficiency of miRNA-149-3p shaped gut microbiota and enhanced dextran sulfate sodium-induced colitis

24 Sept 2022

Abstract excerpt

Genetic predisposition and disruption of host gut microbiota and immune system can result in inflammatory bowel disease (IBD). Here, we show that miRNA-149-5p (miR-149-5p) and miRNA-149-3p (miR-149-3p) play crucial roles in IBD. Mice lacking miR-149-3p were considerably more susceptible to dextran sulfate sodium (DSS)-induced colitis than wild-type (WT) mice, accompanied by more serious inflammatory symptoms and...

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PMID: 36250208
DOI: 10.1016/j.omtn.2022.09.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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