Article
MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis.
Oncotarget - 6 Oct 2015
Runtsch Marah C, Hu Ruozhen, Alexander Margaret, Wallace Jared, Kagele Dominique, Petersen Charisse, Valentine John F, Welker Noah C, Bronner Mary P, Chen Xinjian, Smith Daniel P, Ajami Nadim J, Petrosino Joseph F, Round June L, O'Connell Ryan M
Abstract excerpt
Host-microbial interactions within the mammalian intestines must be properly regulated in order to promote host health and limit disease. Because the microbiota provide constant immunological signals to intestinal tissues, a variety of regulatory mechanisms have evolved to ensure proper immune responses to maintain homeostasis. However, many of the genes that comprise these regulatory pathways, including...
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