Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of MicroRNA-21 Influences the Gut Microbiota, Causing Reduced Susceptibility in a Murine Model of Colitis.

Journal of Crohn's & colitis - 28 Jun 2018

Johnston Daniel G W, Williams Michelle A, Thaiss Christoph A, Cabrera-Rubio Raul, Raverdeau Mathilde, McEntee Craig, Cotter Paul D, Elinav Eran, O'Neill Luke A J, Corr Sinéad C

Abstract excerpt

BACKGROUND AND AIMS: microRNAs regulate gene expression and influence the pathogenesis of human diseases. The present study investigated the role of microRNA-21 [miR-21] in the pathogenesis of intestinal inflammation, because miR-21 is highly expressed in inflammatory bowel disease. Inflammatory bowel disease is associated with intestinal barrier dysfunction and an altered gut microbiota. Recent studies have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Colitis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dextran Sulfate

Share to Gastrointestinal Microbiome

Share to MicroRNAs

Share to Protective Factors

Share to RNA, Ribosomal, 16S

Source

Identifiers

PMID: 29608690
DOI: 10.1093/ecco-jcc/jjy038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Loss of MicroRNA-21 Influences the Gut Microbiota, Causing Reduced Susceptibility in a Murine Model of Colitis.PMID 29608690Read ↗

Divergent influence of microRNA-21 deletion on murine colitis phenotypes.Semantic proximity Read ↗

Deficiency of miRNA-149-3p shaped gut microbiota and enhanced dextran sulfate sodium-induced colitisSemantic proximity Read ↗

Human-derived microRNA 21 regulates indole and L-tryptophan biosynthesis transcripts in a prominent gut symbiontSemantic proximity Read ↗

Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency.Semantic proximity Read ↗

MicroRNA-21 Plays Multiple Oncometabolic Roles in Colitis-Associated Carcinoma and Colorectal Cancer via the PI3K/AKT, STAT3, and PDCD4/TNF-α Signaling Pathways in ZebrafishSemantic proximity Read ↗

Human-derived microRNA 21 regulates indole and L-tryptophan biosynthesis transcripts in the gut commensal Bacteroides thetaiotaomicronSemantic proximity Read ↗

Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice.Semantic proximity Read ↗

Depletion of Murine Intestinal Microbiota: Effects on Gut Mucosa and Epithelial Gene ExpressionSemantic proximity Read ↗

Evaluation of level of expression of microRNA-21 and let-7g in serum and stool of patients with colorectal cancerSemantic proximity Read ↗

MicroRNA‐21 increases the expression level of occludin through regulating ROCK1 in prevention of intestinal barrier dysfunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.