Article
Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence.
Genome research - 1 Aug 2012
Gordon Lavinia, Joo Jihoon E, Powell Joseph E, Ollikainen Miina, Novakovic Boris, Li Xin, Andronikos Roberta, Cruickshank Mark N, Conneely Karen N, Smith Alicia K, Alisch Reid S, Morley Ruth, Visscher Peter M, Craig Jeffrey M, Saffery Richard
Abstract excerpt
Comparison between groups of monozygotic (MZ) and dizygotic (DZ) twins enables an estimation of the relative contribution of genetic and shared and nonshared environmental factors to phenotypic variability. Using DNA methylation profiling of ∼20,000 CpG sites as a phenotype, we have examined discordance levels in three neonatal tissues from 22 MZ and 12 DZ twin pairs. MZ twins exhibit a wide range of within-pair...
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