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Article

Effects of NR1I2 and ABCB1 Genetic Polymorphisms on Everolimus Pharmacokinetics in Japanese Renal Transplant Patients.

International journal of molecular sciences - 3 Oct 2022

Yagishita Hironobu, Kagaya Hideaki, Saito Mitsuru, Numakura Kazuyuki, Yamamoto Ryohei, Sagehashi Ryuichiro, Habuchi Tomonori, Satoh Shigeru, Miura Masatomo

Abstract excerpt

The purpose of this study was to evaluate the effects of NR1I2 (7635G>A and 8055C>T) and ABCB1 (1236C>T, 2677G>T/A, and 3435C>T) genetic polymorphisms on everolimus pharmacokinetics in 98 Japanese renal transplant patients. On day 15 after everolimus administration, blood samples were collected just prior to and 1, 2, 3, 4, 6, 9, and 12 h after administration. The dose-adjusted area under the blood...

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Identifiers

PMID: 36233042
DOI: 10.3390/ijms231911742
PMCID: PMC9570057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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