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Article

Influence of pharmacokinetics-related polymorphisms on asciminib exposure in patients with Japanese chronic myeloid leukemia.

European journal of clinical pharmacology - 19 Jan 2026

Takahashi Naoto, Akamine Yumiko, Miura Masatomo

Abstract excerpt

PURPOSE: The effects of polymorphisms in CYP3A4, UGT2B7, ABCB1, ABCG2, ABCC2, NR1I2, and AHR genes on asciminib exposure were evaluated in Japanese patients with chronic myeloid leukemia. METHODS: Plasma concentrations of asciminib (40 mg twice daily [BID] or 80 mg once daily [QD]) were measured by high-performance liquid chromatography. Statistical analysis was performed using SPSS (P < 0.05). RESULTS: For both...

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Source

Identifiers

PMID: 41553485
DOI: 10.1007/s00228-025-03981-w

Genes

BID
NR1I2
ABCB1
ABCC2
ABCG2
AHR
CYP3A4
UGT2B7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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