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Article

GSTT1/GSTM1 Genotype and Anti-Tuberculosis Drug-Induced Hepatotoxicity in Peruvian Patients.

International journal of molecular sciences - 20 Sept 2022

Jaramillo-Valverde Luis, Levano Kelly S, Tarazona David D, Vasquez-Dominguez Andres, Toledo-Nauto Anel, Capristano Silvia, Sanchez Cesar, Tarazona-Santos Eduardo, Ugarte-Gil Cesar, Guio Heinner

Abstract excerpt

In Peru, 24,581 people were diagnosed with tuberculosis (TB) in 2020. Although TB treatments are effective, 3.4-13% are associated with significant adverse drug reactions (ADRs), with drug-induced liver injury (DILI) considered the most predominant. Among the first-line antituberculosis drugs, isoniazid (INH) is the main drug responsible for the appearance of DILI. In the liver, INH is metabolized by the enzymes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36232322
DOI: 10.3390/ijms231911028
PMCID: PMC9569635

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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