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Article

NAT2 and CYP2E1 polymorphisms and antituberculosis drug-induced hepatotoxicity in Peruvian patients.

Molecular genetics & genomic medicine - 1 Aug 2022

Jaramillo-Valverde Luis, Levano Kelly S, Tarazona David D, Capristano Silvia, Zegarra-Chapoñan Roberto, Sanchez Cesar, Yufra-Picardo Velia M, Tarazona-Santos Eduardo, Ugarte-Gil Cesar, Guio Heinner

Abstract excerpt

BACKGROUND: In Peru, 32,970 people were diagnosed with tuberculosis (TB) in 2019. Although TB treatment is effective, 3.4%-13% is associated with significant adverse drug reactions (ADR), considering drug-induced liver injury (DILI) as the most prevalent. Among the first-line anti-TB drugs, isoniazid (INH) is primarily responsible for the occurrence of DILI. INH is metabolized in the liver by the enzymes...

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Share to Antitubercular Agents
Share to Arylamine N-Acetyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemical and Drug Induced Liver Injury

Share to Cross-Sectional Studies

Share to Cytochrome P-450 CYP2E1

Share to Polymorphism, Single Nucleotide

Share to Tuberculosis

Source

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Identifiers

PMID: 35751408
DOI: 10.1002/mgg3.1987
PMCID: PMC9356556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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