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Development of amidase-dependent pyrazinoic acid prodrugs with activity against pyrazinamide resistant <i>Mycobacterium tuberculosis</i>

2022-07-05

Abstract excerpt

<h4>ABSTRACT</h4> Rapid emergence of drug resistance in Mycobacterium tuberculosis (Mtb) is one of the most significant healthcare challenges of our time. The cause of drug resistance is multifactorial, with the long course anti-tubercular therapy required to treat tuberculosis (TB) constituting a major contributing factor. Introduction of pyrazinamide (PZA) resulted in shortening of TB treatment from twelve to...

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Literature Corpus work
5a365596-b0e6-51cc-a712-b320c6e3c269
DOI
10.1101/2022.07.05.496887
Open publication

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