Article
Revealing the functions of clonal driver gene mutations in patients based on evolutionary dependencies.
Human mutation - 1 Dec 2022
Lan Yujia, Liu Wei, Hou Xiaobo, Wang Shuai, Wang Hao, Deng Menglan, Wang Guiyu, Ping Yanyan, Zhang Xinxin
Abstract excerpt
The clonal mutations in driver genes enable cells to gradually acquire growth advantage in tumor development. Therefore, revealing the functions of clonal driver gene mutations is important. Here, we proposed the method FCMP that considered evolutionary dependencies to analyze the functions of clonal driver gene mutations in a single patient. Applying our method to five cancer types from The Cancer Genome Atlas,...
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