Article
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing.
Neuro-oncology - 2 Jun 2023
Demirdizen Engin, Al-Ali Ruslan, Narayanan Ashwin, Sun Xueyuan, Varga Julianna Patricia, Steffl Bianca, Brom Manuela, Krunic Damir, Schmidt Claudia, Schmidt Gabriele, Bestvater Felix, Taranda Julian, Turcan Şevin
Abstract excerpt
BACKGROUND: IDH mutant gliomas are grouped into astrocytomas or oligodendrogliomas depending on the codeletion of chromosome arms 1p and 19q. Although the genomic alterations of IDH mutant gliomas have been well described, transcriptional changes unique to either tumor type have not been fully understood. Here, we identify Tripartite Motif Containing 67 (TRIM67), an E3 ubiquitin ligase with essential roles during...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.