Article
TRIM56 acts through the IQGAP1-CDC42 signaling axis to promote glioma cell migration and invasion.
Cell death & disease - 4 Mar 2023
Zhang Qing, Zheng Jianglin, Wu Wenjie, Lian Haiyan, Iranzad Natasha, Wang Endi, Yang Lianhe, Wang Xuan, Jiang Xiaobing
Abstract excerpt
Diffuse invasion is an important factor leading to treatment resistance and a poor prognosis in gliomas. Herein, we found that expression of the tripartite motif containing 56 (TRIM56), a RING-finger domain containing E3 ubiquitin ligase, was markedly higher in glioma than in normal brain tissue, and was significantly correlated with malignant phenotypes and a poor prognosis. In vitro and in vivo experimental...
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