Article
Coincidence of v-raf murine sarcoma viral oncogene homolog B mutation (V595E) with phosphorylated v-raf murine sarcoma viral oncogene homolog B in urothelial carcinoma in dogs.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire - 1 Oct 2022
Yamasaki Hirofumi, Uematsu Yosuke, Hayashi Yuhei, Yamashita Masao, Tei Meina, Uchida Kazuyuki, Ono Kenichiro, Hirao Hidehiro
Abstract excerpt
Expression of phosphorylated v-raf murine sarcoma viral oncogene homolog B (pBRAF) and phosphorylated extracellular signal-regulated kinase1/2 (pERK1/2) were investigated in urothelial carcinoma (UC) in dogs with or without the BRAF gene mutation (V595E). Among the 10 cases of UC with V595E (-), cytoplasmic immunoreactivity against pBRAF of neoplastic cells was reported in 8, with 7 displaying moderate reactivity...
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