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Article

BRAF Mutations in Canine Cancers.

PloS one - 1 Jan 2015

Mochizuki Hiroyuki, Kennedy Katherine, Shapiro Susan G, Breen Matthew

Abstract excerpt

Activating mutations of the BRAF gene lead to constitutive activation of the MAPK pathway. Although many human cancers carry the mutated BRAF gene, this mutation has not yet been characterized in canine cancers. As human and canine cancers share molecular abnormalities, we hypothesized that BRAF gene mutations also exist in canine cancers. To test this hypothesis, we sequenced the exon 15 of BRAF, mutation hot...

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Identifiers

PMID: 26053201
DOI: 10.1371/journal.pone.0129534
PMCID: PMC4460039

Genes

BRAF

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