Back to search

Article

Aberrant expression of the COX2/PGE <sub>2</sub> axis is induced by activation of the RAF/MEK/ERK pathway in BRAF <sup>V595E</sup> canine urothelial carcinoma

2019-10-01

Abstract excerpt

Cancer-promoting inflammation is an important event in cancer development. The cyclooxygenase 2 (COX2)/prostaglandin E2 (PGE 2 ) axis is a prominent inducer of inflammation. Canine urothelial carcinoma (cUC) uniquely overexpresses PGE 2 and is often managed well with COX inhibitor monotherapy. In most cases, cUC tissue harbours homologous human BRAF V600E mutation, which causes aberrant activation of the RAF/ME...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4fdc76b3-604a-5823-b312-72f94582799a
DOI
10.1101/786095
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Aberrant expression of the COX2/PGE <sub>2</sub> axis is induced by activation of the RAF/MEK/ERK pathway in BRAF <sup>V595E</sup> canine urothelial carcinomaDOI 10.1101/786095
Comparative Aspects of BRAF Mutations in Canine CancersSemantic proximity
Expression of Cyclo-oxygenase-2 in Naturally Occurring Squamous Cell Carcinomas in DogsSemantic proximity
Identifying the ErbB/MAPK Signaling Cascade as a Therapeutic Target in Canine Bladder Cancer.Semantic proximity
Comprehensive gene expression analysis of canine invasive urothelial bladder carcinoma by RNA-SeqSemantic proximity
Establishment of Canine Transitional Cell Carcinoma Cell Lines Harboring BRAF V595E Mutation as a Therapeutic Target.Semantic proximity
Establishment of a BRAF V595E-mutant canine prostate cancer cell line and the antitumor effects of MEK inhibitors against canine prostate cancer.Semantic proximity
Phase I/II Trial of Vemurafenib in Dogs with Naturally Occurring, BRAF-mutated Urothelial Carcinoma.Semantic proximity
A reversible SRC-relayed COX2-inflammatory program drives therapeutic resistance in BRAF <sup>V600E</sup> colorectal tumorsSemantic proximity
New insights into the functions of Cox-2 in skin and esophageal malignanciesSemantic proximity
Cyclooxygenase‐2 modulates cellular growth and promotes tumorigenesisSemantic proximity
BRAFV595E Mutation Associates CCL17 Expression and Regulatory T Cell Recruitment in Urothelial Carcinoma of Dogs.Semantic proximity
[Cyclooxygenase 2 and carcinogenesis].Semantic proximity
Select a neighboring publication to make it the new centre.