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Article

Proteomic Signatures of Vemurafenib Resistance in Canine Urothelial Carcinoma Harboring the BRAFV595E Mutation.

Journal of proteome research - 7 Aug 2026

Mohallem Rodrigo, Dhawan Deepika, Enstrom Alexander W, Knapp Deborah W, Aryal Uma K

Abstract excerpt

Naturally occurring canine invasive urothelial carcinoma (InvUC) often harbors a BRAFV595E mutation, analogous to human BRAFV600E found across multiple cancer types, and has been used to investigate the effects of BRAF-targeted therapy. To investigate proteomic and phosphoproteomic changes during therapy, we analyzed 42 samples from 14 dogs with BRAFV595E-positive InvUC treated with vemurafenib. Tumors were...

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Identifiers

PMID: 42359562
DOI: 10.1021/acs.jproteome.6c00246
PMCID: PMC13459542

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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