Article
Rapid and highly sensitive detection of MYD88/CXCR4 mutations in Waldenström macroglobulinemia by MAS-qPCR: A pilot study.
Clinical biochemistry - 1 Aug 2026
Kunimune Yuki, Nishioka Mitsuaki, Namba Haruka, Todaka Kimika, Fujii Tomohiro, Kiso Nayu, Nakahara Yukiko, Shinkawa Kanae, Kumano Yumiko, Kodama Masaki, Ebisui Tomoya, Nishimoto Ryoga, Okayama Naoko, Suehiro Yutaka, Yamasaki Takahiro, Yujiri Toshiaki
Abstract excerpt
BACKGROUND: Waldenström macroglobulinemia (WM) is a subset of lymphoplasmacytic lymphoma characterized by bone marrow infiltration of tumor cells and IgM monoclonal gammopathy. MYD88 mutations are found in more than 90% of WM patients and CXCR4 mutations in approximately 30-40%. For this reason, MYD88 mutation analysis is particularly important for the definitive diagnosis of WM. Furthermore, the CXCR4 S338*...
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