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Discovery of Novel Acetohydroxyacid Synthase Inhibitors as Active Agents against<i>Mycobacterium tuberculosis</i>by Virtual Screening and Bioassay

14 Jan 2013

Abstract excerpt

Acetohydroxyacid synthase (AHAS) has been regarded as a promising drug target against Mycobacterium tuberculosis (MTB) as it catalyzes the biosynthesis of branched-chain amino acids. In this study, 23 novel AHAS inhibitors were identified through molecular docking followed by similarity search. The determined IC(50) values range from 0.385 ± 0.026 μM to >200 μM against bacterium AHAS. Five of the identified...

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PMID: 23316686
DOI: 10.1021/ci3004545

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