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Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis

5 Jul 2017

Abstract excerpt

Significance Tuberculosis, caused by Mycobacterium tuberculosis ( Mtb ) bacteria, is the most prevalent infectious disease, affecting one-third of the global population, especially in developing countries. First-line therapies to treat this disease are losing efficacy due to the emergence of drug resistance. Accordingly, new therapeutic agents of novel mechanisms of action remain an urgent medical need. The...

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PMID: 28679637
DOI: 10.1073/pnas.1706134114

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