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Article

Preferential MGMT hypermethylation in SDH-deficient wild-type GIST.

Journal of clinical pathology - 14 Dec 2023

Giger Olivier T, Ten Hoopen Rogier, Shorthouse David, Abdullahi Shukri, Bulusu Venkata Ramesh, Jadhav Saili, Maher Eamonn R, Casey Ruth T

Abstract excerpt

AIMS: Wild-type gastrointestinal stromal tumours (wtGIST) are frequently caused by inherited pathogenic variants, or somatic alterations in the succinate dehydrogenase subunit genes (SDHx). Succinate dehydrogenase is a key enzyme in the citric acid cycle. SDH deficiency caused by SDHx inactivation leads to an accumulation of succinate, which inhibits DNA and histone demethylase enzymes, resulting in global...

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Share to DNA Methylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair Enzymes

Share to Epigenesis, Genetic

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Share to Protein-Tyrosine Kinases

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Source

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Identifiers

PMID: 36198483
DOI: 10.1136/jcp-2022-208462
PMCID: PMC10804026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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