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Article

Recurrent epimutation of SDHC in gastrointestinal stromal tumors.

Science translational medicine - 24 Dec 2014

Killian J Keith, Miettinen Markku, Walker Robert L, Wang Yonghong, Zhu Yuelin Jack, Waterfall Joshua J, Noyes Natalia, Retnakumar Parvathy, Yang Zhiming, Smith William I, Killian M Scott, Lau C Christopher, Pineda Marbin, Walling Jennifer, Stevenson Holly, Smith Carly, Wang Zengfeng, Lasota Jerzy, Kim Su Young, Boikos Sosipatros A, Helman Lee J, Meltzer Paul S

Abstract excerpt

Succinate dehydrogenase (SDH) is a conserved effector of cellular metabolism and energy production, and loss of SDH function is a driver mechanism in several cancers. SDH-deficient gastrointestinal stromal tumors (dSDH GISTs) collectively manifest similar phenotypes, including hypermethylated epi...

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Share to DNA Methylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25540324
DOI: 10.1126/scitranslmed.3009961
PMCID: PMC7670881

Genes

SDHC
SDHB
KIT
PDGFRA
SDHA
SDHD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25540324-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Recurrent epimutation of SDHC in gastrointestinal stromal tumors.PMID 25540324Read ↗

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SDHC methylation in gastrointestinal stromal tumors (GIST): a case report.Semantic proximity Read ↗

SDHA Germline Mutations in SDH-Deficient GISTs: A Current Update.Semantic proximity Read ↗

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