Molecular Subtypes of<i>KIT/PDGFRA</i>Wild-Type Gastrointestinal Stromal Tumors

Abstract excerpt

IMPORTANCE: Wild-type (WT) gastrointestinal stromal tumors (GISTs), which lack KIT and PDGFRA gene mutations, are the primary form of GIST in children and occasionally occur in adults. They respond poorly to standard targeted therapy. Better molecular and clinical characterization could improve management. OBJECTIVE: To evaluate the clinical and tumor genomic features of WT GIST. DESIGN, SETTING, AND...

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