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An epigenetic association analysis of childhood trauma in psychosis reveals possible overlap with methylation changes associated with PTSD

30 Apr 2022

Abstract excerpt

Patients with a severe mental disorder report significantly higher levels of childhood trauma (CT) than healthy individuals. Studies have suggested that CT may affect brain plasticity through epigenetic mechanisms and contribute to developing various psychiatric disorders. We performed a blood-based epigenome-wide association study using the Childhood Trauma Questionnaire-short form in 602 patients with a current...

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PMID: 35501310
DOI: 10.1038/s41398-022-01936-8

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