Article
Experimental evidence for the correlation between RNA structural fluctuations and the frequency of beneficial mutations.
RNA (New York, N.Y.) - 1 Dec 2022
Maeda Yutaro, Mizuuchi Ryo, Shigenobu Shuji, Shibai Atsushi, Kotani Hazuki, Furusawa Chikara, Ichihashi Norikazu
Abstract excerpt
RNA has been used as a model molecule to understand the adaptive evolution process owing to the simple relationship between the structure (i.e., phenotype) and sequence (i.e., genotype). RNA usually forms multiple substructures with similar thermodynamic stabilities, called structural fluctuations. Ancel and Fontana theoretically proposed that structural fluctuation is directly related to the ease of change in...
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